Aiyuk, who who currently is on the 49ers' Reserve/Left Squad list, has turned in paperwork to be reinstated, Adam Schefter of ESPN reports.
Per his agent Drew Rosenhaus, Aiyuk "is healthy and ready to get back on the field." Meanwhile, Schefter adds that once the wideout officially reports back to the 49ers, the team's options are to keep Aiyuk under his current contract, release him or look to move him ahead of this coming Tuesday's NFL trade deadline. Given the moving parts involved, it remains to be seen when Aiyuk might return to the field in any locale, but depending on his health and conditioning level, the 2020 first-rounder could represent an intriguing option for a team looking to add WR depth to consider.
Sigle (ankle) was limited in Wednesday's practice.
Sigle hasn't played since Week 4 due to a high-ankle sprain. He started each of the first four games of the season and logged 26 tackles (13 solo), including 1.0 sacks, on 238 defensive snaps during that span. Sigle appears to be nearing a return to action.
Kirk (knee) was limited in Wednesday's practice, Sam Warren of The Athletic reports.
It's a new injury for Kirk, who made his season debut in Week 7 against the Falcons after missing the first six games with a calf injury. The Niners are coming off their bye and are hoping to get some reinforcements at wide receiver, with Demarcus Robinson (ankle) limited Wednesday, while Mike Evans (ribs/Achilles) and Deebo Samuel (hamstring) logged DNPs.
Bosa (knee) was limited in Wednesday's practice, Sam Warren of The Athletic reports.
It was Bosa's first practice since suffering a knee injury in Week 2 that has forced him to miss the last five contests. Coming out of the Week 8 bye, the Niners are getting healthy. In two games this season, Bosa has seven tackles (three solo) across 76 defensive snaps.
Samuel (hamstring) won't take part in practice Wednesday, Cam Inman of The San Jose Mercury News reports.
Samuel injured his right hamstring during a Week 5 win at Seattle, resulting in two missed games before the 49ers' Week 8 bye. Head coach Kyle Shanahan relayed to Matt Maiocco of NBC Sports Bay Area on Oct. 26 that Samuel has a chance to return this Sunday against the Raiders, but Shanahan's tone was a bit different Wednesday, when he told Vic Tafur and Matt Barrows of The Athletic that Samuel doesn't seem as close to playing as fellow WR Mike Evans (Achilles).
Head coach Kyle Shanahan said Evans (Achilles/ribs) won't practice Wednesday, NFL reporter Andrew Siciliano reports.
Evans sat out a Week 7 loss in Atlanta after aggravating a right Achilles injury in Week 6 against the Commanders, and while there's an expectation that he'll be back after a Week 8 bye, he'll kick off this week with a DNP. He thus will have two more chances to mix into drills ahead of Sunday's contest versus the Raiders.
McCaffrey (hamstring) will not participate in Wednesday's practice, Cam Inman of Bay Area News Group reports.
Three key vets are not taking part in the first practice out of the bye Wednesday as McCaffrey, Mike Evans (Achilles/ribs) and Deebo Samuel (hamstring) are all sidelined for this session. McCaffrey has been dealing with a hamstring issue since the Week 7 game in Atlanta. Coach Kyle Shanahan said Wednesday that McCaffrey is "not going today but hopefully a chance [Thursday]." The next few days of practice will be telling for McCaffrey's status going into Sunday's game against the Raiders.
Stout (shoulder) was only active as an emergency depth option during Sunday's loss to the Falcons, David Lombardi of SFStandard.com reported Monday.
Coach Kyle Shanahan said that Stout was only going to enter the game in an emergency scenario for the 49ers' secondary. The team hopes the Week 8 bye will allow Stout's shoulder sprain to fully heal ahead of the Week 9 showdown with the Raiders.
The 49ers designated Hobbs (groin) for return to practice from their injured reserve list Wednesday.
Hobbs went to IR with a groin injury prior to San Francisco's regular-season debut, but it now looks like he's getting close to returning to action. The 49ers will have 21 days to officially activate him before he'd have to remain on IR for the rest of the campaign.
Robinson (ankle) was designated to return from injured reserve Wednesday, Matt Maiocco of NBC Sports Bay Area reports.
Robinson made his return to practice Wednesday, logging a limited session at the team's first gathering of the week, Nick Wagoner of ESPN.com reports. The wide receiver has been sidelined since suffering a high-ankle sprain in Week 2 against the Dolphins, but he could be nearing a return to action.
Stribling (ankle) was spotted Monday walking without crutches or a brace on his lower leg, Matt Barrows of The Athletic reports.
Stribling, who garnered his share of preseason fantasy buzz, was injured in the 49ers' Week 1 win over the Rams, but it appears as though the wideout is making solid progress in his recovery. A firm timetable for the 2026 second-rounder's return to practice hasn't been outlined yet, but David Lombardi of SFStandard.com previously noted that Stribling (ankle) remains on track to return at some point in December, a notion supported by Barrows' report.
Head coach Kyle Shanahan said Monday that Martin's (hamstring) status will be evaluated "in these next couple of days," Nick Wagoner of ESPN.com reports.
Martin opened the regular season on injured reserve due to a hamstring injury that he sustained during training camp in August. Shanahan said Martin is "getting close" to returning to practice, and if he's cleared for field work this week, his participation level will shed light on whether he'll play in Week 6 against the Commanders on Monday, Oct. 19. The 2025 third-rounder logged 11 tackles (eight solo) and one fumble recovery across seven regular-season games during his rookie campaign, which he finished on injured reserve due to a concussion.
The 49ers placed West (undisclosed) on injured reserve Wednesday.
It remains unclear what issue is sidelining the second-year player. West will now need to miss at least four games on IR before becoming eligible to return to the active roster. The defensive tackle has logged five tackles (one solo) over 49 defensive snaps in the 49ers' first two regular-season games.
Tonges (knee) requires surgery for an MCL tear and is done for the season, Cam Inman reports.
The team placed Tonges on injured reserve earlier Wednesday, and now it's official that he will miss the rest of the season. Tonges suffered an MCL tear in the season opener against the Rams. Jack Stoll was signed to the practice squad to add depth, and Luke Farrell now projects to be the second tight end behind George Kittle.
San Francisco placed Collins (knee) on injured reserve Thursday.
This move was anticipated, as Collins is set to miss the entire 2026 campaign as a result of tearing his patellar tendon during practice Tuesday. Osa Odighizuwa, CJ West and Gracen Halton should get plenty of reps at defensive tackle with Collins and Sam Okuayinonu (foot) sidelined.
Okuayinonu broke his foot in practice last week and is set to have surgery to repair the issue, Matt Barrows of The Athletic reports.
Head coach Kyle Shanahan said Monday he hopes Okuayinonu can return near the end of the regular season, but it is unclear quite how long the recovery process will take. Okuayinonu previously had a plate in his foot, and the break occurred when it was stepped on during practice.
Zakelj (undisclosed) was placed on the 49ers' injured reserve Sunday.
The nature of Zakelj's injury is unclear, as is when he exactly picked up the injury. However, by being placed on IR without a designation to return, the 2022 sixth-rounder will be forced to miss the entire upcoming season unless he reached an injury settlement with San Francisco.
The 49ers placed Pleasants (knee) on injured reserve with a designation to return Sunday.
Pleasants sustained a knee injury during the 49ers' preseason game against the Chargers on Aug. 20. The injury is severe enough for 29-year-old offensive tackle to open the year on IR, meaning he'll be forced to miss at least the first four games of the regular season.
Guerendo (pectoral) was placed on the reserve/PUP list Sunday, Jeremy Fowler of ESPN reports.
Guerendo spent all of training camp on the active/PUP list and is seemingly not ready to take the field, so he will remain on PUP and will miss at least the first four weeks of the season. As such, Kaelon Black and Jordan James will open as the top two options behind starter Christian McCaffrey (undisclosed).
Pearsall announced Thursday in a post on his personal Instagram account that he underwent season-ending surgery to repair the PCL in his right knee, David Lombardi of SFStandard.com reports.
The procedure typically carries a wide-ranging recovery timeline of 6-to-12 months, so while Pearsall will be ruled out for the season, it's not clear if he'll be available for the start of the 49ers' offseason program next spring or the start of training camp next summer. The wideout will wind up having played in just 20 of a possible 51 regular-season contests and one of two playoff games through his first three NFL campaigns, missing time as a rookie while recovering from a gunshot wound to the chest before being hampered by the PCL injury off and on in 2025. He'll turn 27 in September and will be entering the final season of his rookie contract in 2027.
Kamara (knee) reverted to the 49ers' injured reserve Monday, per the NFL's transaction log.
Matt Maiocco of NBC Sports Bay Area reports Kamara suffered a torn ACL. The undrafted free agent out of Indiana will now spend the duration of the 2026 season on IR unless he and the 49ers reach an injury settlement.
San Francisco placed Farmer (back) on its injured-reserve list Thursday, Aaron Wilson of KPRC 2 Houston reports.
Farmer was not picked up by another squad after the 49ers waived him with an injury designation earlier in the week, and now he'll be required to stay on the team's IR list for the year unless he negotiates an injury settlement. He last played regular-season snaps in 2023 with the Chargers.
San Francisco placed Forrest (undisclosed) on its injured reserve list Thursday.
It's not clear what kind of injury Forrest is dealing with, but he's now on track to spend the entire 2026 season on IR unless he negotiates an injury settlement with the 49ers. His absence could open up more opportunities for rookie undrafted free agents Jalen Stroman and Larry Worth.
Greenlaw posted 12 tackles (four solo) in Sunday's loss to the Falcons.
Greenlaw missed Week 6 against Washington while on suspension but returned Sunday and logged a season-high 91 percent defensive snap share. The veteran linebacker tied his season high with 12 tackles, finishing one behind Fred Warner for the team lead. Greenlaw is enjoying a productive return to San Francisco with 49 tackles and a forced fumble through six contests.
Warner recorded 13 tackles (six solo) Sunday in a Week 7 loss to Atlanta.
Warner led the 49ers in tackles, finishing one ahead of Dre Greenlaw. It was the fourth time through seven games that Warner has notched double-digit stops. The star linebacker ranks second in the NFL with 71 tackles through seven games.
